A brief history of tyrosine phosphorylation with The King of Kinases

Tony Hunter (left) is a professor at the Salk Institute for Biological Studies (CA, USA), where his lab aims to decipher the molecular basis of cell proliferation and cell cycle regulation, and the mechanisms underlying the conversion of normal cells into cancer cells. They investigate post-translational modifications of proteins, particularly phosphorylation – the covalent attachment of phosphate to a protein - with histidine phosphorylation a key area of interest. In this interview from the meeting of the American Association for Cancer Research (5th–10th April 2024; San Diego, CA, USA), where Tony was awarded the Princess Takamatsu Memorial Lectureship, Tony discusses...