Identification of a tumor-specific gene regulatory network in human B-cell lymphoma
Simultaneous readout of transcriptomic and epigenomic data from the same cell at single-cell resolution allows for direct reconstruction of cell type–specific gene regulatory networks that do not rely on inference or assumptions to tie the two data types together. This data spotlight provides an example of the value added by analyzing two simultaneously collected data types and the tools available to both collect and analyze this data.
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Discover how to investigate the genes are expressed in a single cell and how expression is regulated through associated open chromatin regions in this data spotlight paper.
Highlights:
- Distinguish tumor versus normal cells in a heterogeneous sample
- Reconstruct cell type–specific gene regulatory network
- Confirm PAX5 as a critical regulator specific to tumor B cells
- Identify putative target genes downstream of PAX5
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