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Enriching pathological analysis of FFPE tumor samples with spatial transcriptomics

Written by 10x Genomics
Cancer research Cell and tissue biology PCR and sequencing

Formalin-fixed paraffin-embedded (FFPE) samples are a valuable resource for diagnosing prostate cancers. Properly stratifying disease severity and identifying the best therapeutic strategies could be aided by complementing traditional pathological assessment with spatial gene expression insights.

This Application Note from 10x Genomics discusses how you can use spatial transcriptomics to analyze FFPE tumor samples.

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This Application Note details how tissue-wide whole transcriptome analysis with Visium Spatial Gene Expression for FFPE was used to resolve the tumor microenvironment of two prostate cancer samples. We identify well-known prostate cancer markers and reveal the spatial organization of key cell types,
including epithelial and immune cells.

This content was provided by 10x Genomics