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Application Note: spatially-resolved heterogeneity of triple-negative breast cancer

Written by 10x Genomics
Cancer research Cell and tissue biology Immunology Whole-genome studies

This Application Note by 10x Genomics illustrates how the integration of spatial and single nuclei gene expression data can better characterize triple-negative breast cancer by resolving intratumoral heterogeneity, defining the extent of immune infiltration, and localizing specific cell types and states.

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This Application Note highlights:

  • The characterization of intratumoral heterogeneity within pathologist-annotated invasive carcinoma
  • The integration of spatial and single cell gene expression data to visualize localized enrichment of specific cell subtypes and states
  • The refinement of immune-cell boundaries and immune cell-type composition

… And much more!

This content was provided by 10x Genomics.