Application Note: Real-time live-cell analysis of 3D organoid growth in Matrigel® domes
The recent progress in organoid technology has paved the way for new possibilities in human disease research, disease modeling, regenerative medicine, and precision therapies tailored to individual patients.
In this Application Note, Sartorius demonstrates the use of the Incucyte® Live-Cell Analysis system, in combination with the Incucyte® Organoid Analysis Software Module, to facilitate kinetic assessment of organoid formation and growth.
Organoids, which are differentiated microtissues derived from various types of stem cells, can be developed within 3D extracellular matrices to replicate the architecture and genetic diversity found in vivo.
These self-organizing and self-renewing structures offer a unique advantage over traditional monolayer culture techniques, presenting unparalleled potential for a range of applications. However, to effectively utilize these models in fundamental research, disease modeling, and drug screening, it is crucial to have specific and reliable methods for in vitro culture and analysis.
For more information, check out Sartorius’ website.
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