Sage Science to Distribute Universal Sequencing Technology’s TELL-Seq™ Linked-Read NGS Library Prep Kits

Linked-read technology paired with SageHLS instrument enables targeted sequencing of large gene targets using short-read sequencers

BEVERLY, Mass., and CANTON, Mass. — October 26, 2020 — Sage Science, a developer of products for improving sample preparation processes in life science applications, and Universal Sequencing Technology today announced a distribution agreement to improve scientists’ access to long-range genomic information produced from short-read sequencing platforms. Through the agreement, Sage Science will distribute Universal Sequencing Technology’s TELL-Seq kits to biologists in the U.S., including to users of its HLS-CATCH™ technique for targeting and analyzing large genomic elements.

The HLS-CATCH method uses Cas9 enzymology with the SageHLS instrument to purify large genetic targets directly from cells. The process yields intact genomic regions that are up to 500 kilobases in length, preserving them for analysis with targeted sequencing. TELL-Seq kits can be used to barcode molecules for linked-read analysis that makes it possible to characterize long-range information from short-read sequencing platforms. Together, the methods allow scientists to extract high molecular weight DNA — such as an entire gene — and generate data about structural variants and haplotype that would be difficult to access with a conventional short-read sequencing technique.

“We are committed to helping scientists generate better and more cost-effective results from existing DNA analysis technologies through improved sample prep workflows,” said Chris Boles, PhD, Chief Scientific Officer at Sage Science. “By distributing TELL-Seq kits to our SageHLS users and other researchers, we can leverage the enormous installed base of short-read sequencers and empower genomic scientists to produce long-range genomic data.”
The TELL-Seq kit can be used with very low sample inputs for de novo DNA sequencing. The whole procedure can be carried out easily in a PCR tube without the need for expensive instrumentation.
“The partnership with Sage Science not only creates another sales distribution channel for our TELL-Seq WGS Library Prep Kits, but it will also lead to an expanded product roadmap with linked-read kits customized for specific genomic targets,” said Tom Chen, PhD, Chief Scientific Officer at Universal Sequencing Technology.
Sage Science will be presenting results from an analysis of the BRCA1 and BRCA2 genes using the HLS-CATCH method and TELL-Seq kits at its virtual booth at the upcoming annual meeting of the American Society of Human Genetics, taking place Oct 27-30.

This content was supplied by Sage Science and Universal Sequencing Technology Corporation.