Gaetan Burgio of the Australian National University (Canberra, Australia) discusses the off-target effects of CRISPR, how they occur, how to avoid them and their impacts on the uses of the technique. CRISPR gene editing technology has been transformative in investigating important biological questions or studying the function of genes. Importantly the technology shows a lot … Continue reading What are off-target effects of CRISPR and why are they concerning?