Single domain antibodies

Single domain antibodies (sdAbs), also known as VHH antibodies or nanobodies™, are small antigen-binding fragments derived from camelids that have a single monomeric variable antibody domain. sdAbs have unique characteristics, most notably their small size, that offer several advantages and make them useful alternatives to conventional antibodies. Their unique attributes and capabilities mean they are being utilized in various fields, from basic research and imaging to diagnostics and therapeutics, and as the patent on them recently expired, we can expect to see more in the coming years.

In this In Focus, in partnership with ProSci Incorporated, we will explore sdAbs, including their characteristics, development and various applications.