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Improved functional imaging using enzyme-responsive nanoplatforms

Written by The Nanomed Zone, Yuyu Yao (Southeast University Medical School) and Zhen Cheng (Stanford University School of Medicine)
Nanomedicine Opinion

In this opinion piece, Yuyu Yao (Southeast University Medical School, Jiangsu, China) and Zhen Cheng (Stanford University School of Medicine, CA, USA) discuss the potential use of enzyme-responsive nanoplatforms to help improve functional imaging in the context of abdominal aortic aneurysms (AAAs). Abdominal aortic aneurysms (AAAs) are characterized by aortic dilation and wall thinning [1]. High matrix metalloproteinase (MMP) activity and inflammation are associated with aneurysm rupture and may predict poor prognosis [2]. Fortunately, AAAs can be treated when diagnosed early. Currently, aneurysm diameter – a diameter greater than 5.5cm – is the main indication for surgical intervention for AAAs....

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