Nanoparticle platform can deliver siRNA across blood–brain barrier in mouse model of TBI

Researchers from Brigham and Women’s Hospital and Boston Children’s Hospital (both MA, USA) have created a nanoparticle packaging system that can facilitate transport of therapeutics into the brains of mice. The breakthrough could herald a potential new avenue for treatment of traumatic brain injury (TBI), as therapeutics can be delivered regardless of the state of the blood–brain barrier (BBB). Findings published in Science Advances have demonstrated the new technique in a mouse model of TBI. Physicians have long faced challenges when treating patients after TBI, as there is a limited window of time in which the BBB is breached, allowing...