New insights into large genomes

Since Haemophilus influenzae became the first organism to have its entire genome sequenced in 1995, there are now thousands of completed genomes covering archaea, bacteria, and eukarya. However, the term ‘completed genome’ (or sometimes, ‘finished genome’) is commonly a misnomer, as the majority of sequenced genomes contain numerous gaps. These gaps correspond to repetitive regions and structural variants that are too large to be resolved by the short-read sequencing technologies often used to generate the genomes. This review outlines how researchers are now utilizing the advantages of long and ultra-long nanopore sequencing reads to address this challenge, delivering more accurate large genomes for a wide variety of applications.

Read this white paper to understand how researchers utilize the advantages of long nanopore sequencing to deliver more accurate large genomes for a wide variety of applications.