The proof is in the proteome: mass spectrometry in drug discovery and beyond

Matthias Trost (left) is a Professor at Newcastle University (UK) with a lab comprising three focuses: method development for proteomics, the application of mass spectrometry in drug discovery and the study of phagosome biology in macrophages and innate immunity. In this interview from ELRIG Research & Innovation (20-21 March 2024; Manchester, UK), we learn more about how Trost and colleagues are using and developing proteomics methods to aid drug discovery efforts. How have you been utilizing mass spectrometry for drug discovery purposes? Over 10 years ago, we were working with an enzyme class called deubiquitylases (DUBs); these enzymes are attractive...