Antibody discovery

Antibodies are one of the most important classes of biologics in the life sciences. Their ability to bind specifically and tightly to target biomolecules makes them ideal therapeutics, and there are now over 160 antibody therapies approved for use to treat a wide variety of diseases, such as cancers, autoimmune disorders and infectious diseases.

Antibody discovery is a crucial first step in developing antibody therapeutics. Large numbers of antibodies are screened and assessed for their therapeutic potential; these programs rely on high-throughput technologies to quickly identify candidates. Discovery workflows begin with identifying thousands of antibodies against a specific target and then triaging them through a series of in vitro binding and functional assays to identify the top leads.

This Spotlight will explore:

• The various techniques and technologies utilized in antibody discovery
• How high-throughput flow cytometry can be used for successful discovery campaigns
• The emerging role of artificial intelligence in antibody discovery