Charting the spatial landscape of cancer hallmarks
Cancer hallmarks are biological processes unique to tumors and the surrounding tumor microenvironment (TME). As cells acquire cancer hallmarks, they progress from normalcy to malignancy. While bulk analyses have increased our knowledge of these activities, recent advances in spatial transcriptomics have enabled a single-cell, spatial view of the origin and localization of hallmark processes within tumors.
This mini webinar will explore a study, which used spatial transcriptomics to quantify the contribution of cancer cells and the TME to cancer hallmarks, and generated a single-cell, spatial map of cancer hallmark activities in tumors.
What will you learn?
- How spatial transcriptomics can be used to quantify the contribution of cancer cells and the tumor microenvironment to cancer hallmarks
- How to generate a single-cell, spatial map of cancer hallmark activities in tumors
Who may this interest?
- Researchers with an interest in cancer
- Researchers with an interest in spatial biology
Speaker
Eduard Porta-Pardo, PhD
Group Leader
Josep Carreras Leukaemia Research Institute
Eduard Porta-Pardo has a background in immunology and computational biology. He obtained his PhD in Barcelona (Spain) in 2013, and then moved to San Diego (CA, USA) to join Adam Godzik’s (University of California, Riverside; USA) laboratory where they worked on cancer genomics and the use of protein structures to find cancer driver genes and mutations. In 2017 he joined the Barcelona Supercomputing Center, where he worked on germline genetics and tumor immunology, and since 2020 he is a group leader at the Josep Carreras Leukaemia Research Institute in Badalona (Spain). His group works on the integration of multiomics data to understand oncogenesis.
This webinar was recorded on Wednesday 7th September 2022
In association with
