Cerebrospinal fluid immunity in the aging brain
David Gate is an Assistant Professor at Northwestern University and Principal Investigator of the Gate lab (both IL, USA). Recent research by Gate has demonstrated the immune role of cerebrospinal fluid (CSF), the clear liquid found in the central nervous system.
Immune cells of the CSF reflect the pathobiological changes that occur in Alzheimer’s and Parkinson’s diseases. In Alzheimer’s disease, Gate found that CD8+ T effector memory cells were clonally expanded, indicating an adaptive immune response to the age-related neurodegenerative disease. More recently, Gate’s lab explored the mechanisms of immune cell homing to the CSF during cognitive impairment and Lewy body dementia.
The Gate lab aims to find neurodegenerative targets, such as biomarkers or immunotherapeutic targets, for developing potential treatments.
This webinar will focus on the immune role of CSF in the aging and neurodegenerative brain.
What will you learn?
- How the CSF immune system changes with age in cognitively normal individuals versus those with cognitive impairment
- The role of CSF immunity in Alzheimer’s disease
- CSF immune changes associated with Lewy body dementia
Who may this interest?
- Academic researchers in neuroscience
- Academic researchers in immunology
- Translational researchers
- Clinical researchers
Speaker
David Gate, PhD
Assistant Professor
Northwestern University
David Gate is an Assistant Professor at Northwestern University and Principal Investigator of the Gate lab (both IL, USA). His lab’s research falls at the intersection of the immune system and neurodegenerative disease, employing multiomics strategies to interpret immune system changes related to neurodegeneration. His group is particularly interested in the interaction between T cells and neurogenerative disease antigens.
This webinar was recorded on Monday 12th September 2022
In association with
