Simple tweak improves single-cell RNA-seq resolution

Why sequence well, when you could sequence better? A new Seq-Well modification has improved what we can glean from single-cell RNA-seq and shed new light on skin diseases. Single-cell RNA-seq is key to understanding cell biology and working towards new disease treatments; however, while current approaches have become higher throughput and cheaper, those improvements have had a trade-off in terms of lost resolution. Now, a new modification to Seq-Well, a method for the rapid, high-throughput sequencing of RNA from multiple single cells at once, has boosted the amount of information we can retrieve from a sample. Seq-Well was developed by...